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SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Sympathomimetics in glaucoma therapy
clonidine
S01EA04
Forms & Strengths
- Ophthalmic solution: 0.125%
Adult Dosing
- Instill 1 drop in the affected eye(s) up to 4 times daily as directed for glaucoma.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established.
Indications
- Reduction of intraocular pressure in open-angle glaucoma (ophthalmic formulation)
Mechanism of Action
- Alpha-2 adrenergic agonist that reduces aqueous humor production and increases outflow.
Contraindications
- Hypersensitivity to clonidine or any component of the formulation
Adverse Reactions
- Transient burning or stinging upon instillation
- Dry mouth
- Fatigue
- Dizziness
- Hypotension
Drug Interactions
- Beta-blockers: May potentiate bradycardia and AV nodal blockade
- Central nervous system depressants: Enhanced sedative effects
- Antihypertensives: Potential additive hypotensive effect
Curated Content: Needs Vetting Before Put to Clinical Use