← Search & browse all drugs
SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Parasympathomimetics
fluostigmine
S01EB07
Forms & Strengths
- Ophthalmic solution 0.1% (w/v) fluostigmine drops
Adult Dosing
- 1-2 drops in each affected eye 2-3 times daily
Pediatric Dosing
- Use not recommended in children; if required, 1 drop in affected eye 2-3 times daily with close monitoring
Indications
- Primary open-angle glaucoma
- Ocular hypertension
- Secondary glaucoma (e.g., neovascular)
- Miosis induction for diagnostic/therapeutic procedures
Mechanism of Action
- Reversible inhibition of acetylcholinesterase increasing intra‑ocular acetylcholine
- Enhanced muscarinic stimulation of iris sphincter and ciliary muscle → miosis and increased trabecular outflow
Contraindications
- Hypersensitivity to fluostigmine or other anticholinesterases
- Acute angle‑closure (narrow‑angle) glaucoma
- Severe asthma, COPD or bronchospastic disease
- Intestinal or urinary obstruction
- Bradycardia, sinus‑node dysfunction, severe hypotension
Adverse Reactions
- Ocular burning, stinging or itching
- Transient blurred vision
- Headache, photophobia
- Increased lacrimation and brow ache
- Systemic cholinergic effects (salivation, sweating, GI cramps, bronchospasm)
- Rare: retinal irritation or detachment
Drug Interactions
- Anticholinergic agents (e.g., atropine) antagonize miotic effect
- Concurrent miotics (pilocarpine) may cause excessive miosis
- Systemic cholinesterase inhibitors (pyridostigmine) increase cholinergic toxicity
- Beta‑blockers may augment bradycardia when systemic absorption occurs
- Sympathomimetics may reduce ocular hypotensive effect
Curated Content: Needs Vetting Before Put to Clinical Use