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SENSORY ORGANS › OPHTHALMOLOGICALS › MYDRIATICS AND CYCLOPLEGICS › Sympathomimetics excl. antiglaucoma preparations
phenylephrine and ketorolac
S01FB51
Forms & Strengths
- Intracameral solution: phenylephrine 1.0% / ketorolac 0.3%
Adult Dosing
- Intracameral: 0.2 mL injected into the anterior chamber during intraocular surgery (e.g., cataract surgery) as directed to maintain pupil dilation and reduce postoperative pain/inflammation.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established.
Indications
- Administered during intraocular lens replacement surgery to maintain intraoperative mydriasis and prevent postoperative ocular pain and inflammation.
Mechanism of Action
- Phenylephrine is an alpha-1 adrenergic receptor agonist causing contraction of the iris dilator muscle (mydriasis).
- Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin biosynthesis by decreasing the activity of the enzyme cyclooxygenase (COX), reducing inflammation and miosis.
Contraindications
- Hypersensitivity to any component of the product, phenylephrine, or other NSAIDs.
- Active ocular infections.
Adverse Reactions
- Increased intraocular pressure
- Eye irritation
- Posterior capsule opacification
- Corneal edema
- Iritis
Drug Interactions
- Concomitant use of topical ocular NSAIDs may increase the potential for corneal healing issues.
- Potential for additive sympathomimetic effects if systemic adrenergic agents are used concurrently.
Curated Content: Needs Vetting Before Put to Clinical Use