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SENSORY ORGANS › OPHTHALMOLOGICALS › DECONGESTANTS AND ANTIALLERGICS › Sympathomimetics used as decongestants
tetryzoline, combinations
S01GA52
Forms & Strengths
- Ophthalmic solution: Tetryzoline HCl 0.05% + Zinc Sulfate 0.25%
- Ophthalmic solution: Tetryzoline HCl 0.05% + Antazoline phosphate 0.5%
- Ophthalmic solution: Tetryzoline HCl 0.05% + Polyvinyl alcohol / Methylcellulose combinations
Adult Dosing
- Instill 1 to 2 drops in the affected eye(s) up to 4 times daily as needed
- Limit use to 3 to 5 consecutive days to prevent rebound hyperemia
Pediatric Dosing
- Children < 2 years: Contraindicated or not recommended due to systemic absorption risks
- Children >= 2 years: 1 drop in the affected eye(s) up to 3 to 4 times daily under adult supervision
Indications
- Temporary relief of minor eye redness due to minor irritations
- Relief of symptoms of allergic conjunctivitis (when combined with antihistamines)
- Astringent and soothing relief of eye irritation (when combined with zinc sulfate)
Mechanism of Action
- Tetryzoline acts as an alpha-adrenergic agonist, causing vasoconstriction of conjunctival blood vessels
- Reduces conjunctival congestion and edema
- Antazoline (in combinations) acts as an H1-receptor antagonist to block histamine-mediated allergic symptoms
- Zinc sulfate (in combinations) acts as a mild astringent to protect and soothe the ocular mucosa
Contraindications
- Hypersensitivity to tetryzoline or any component of the formulation
- Presence of narrow-angle glaucoma
- Use in children under 2 years of age
- Severe cardiovascular disease or hypertension
Adverse Reactions
- Transient stinging or burning upon instillation
- Reactive hyperemia (rebound congestion) with prolonged use
- Mydriasis (pupil dilation)
- Blurred vision
- Systemic sympathomimetic effects (hypertension, palpitations, headache) with excessive absorption
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Concurrent use may precipitate severe hypertensive crisis
- Tricyclic antidepressants: May potentiate the pressor effects of sympathomimetic amines
- Other topical ophthalmic vasoconstrictors: Increased risk of additive local toxicity and rebound effects
Curated Content: Needs Vetting Before Put to Clinical Use