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SENSORY ORGANS › OPHTHALMOLOGICALS › LOCAL ANESTHETICS › Local anesthetics
oxybuprocaine
S01HA02
Adult Dosing
- Surface anesthesia for tonometry: 1 drop prior to measurement
- Surface anesthesia for short procedures: 1-2 drops instilled 5 minutes before procedure
- Surface anesthesia for minor surgery: 1 drop every 5-10 minutes for up to 3 doses
Pediatric Dosing
- Safety and efficacy not well established in neonates and infants
- Use with caution in children; dosage should be minimized to lowest effective amount
Indications
- Surface local anesthesia for ophthalmology
- Corneal and conjunctival anesthesia for tonometry, gonioscopy, and removal of foreign bodies
- Anesthesia prior to minor ophthalmic surgical procedures
Mechanism of Action
- Estrogen-type local anesthetic that reversibly stabilizes the neuronal membrane
- Decreases permeability of the cell membrane to sodium ions
- Inhibits initiation and conduction of nerve impulses, thereby producing local sensory blockade in the eye
Contraindications
- Known hypersensitivity to oxybuprocaine or other ester-type local anesthetics
- History of hypersensitivity to para-aminobenzoic acid (PABA) derivatives
Adverse Reactions
- Transient stinging, burning, and redness upon instillation
- Temporary blurred vision
- Corneal epithelium damage with prolonged or chronic use
- Allergic contact dermatitis and hypersensitivity reactions
Drug Interactions
- May inhibit the antibacterial activity of sulfonamides
- Concurrent use of other topical ophthalmic drugs may alter absorption or efficacy
Curated Content: Needs Vetting Before Put to Clinical Use