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cinchocaine

S01HA06

Forms & Strengths

Ophthalmic solution: 0.05%
Topical ointment: 0.5%
Topical cream: 0.5%

Adult Dosing

Ophthalmic: Instill 1 to 2 drops into the conjunctival sac prior to minor ocular procedures.
Topical: Apply a thin layer to the affected area up to 3 to 4 times daily as needed for pain and pruritus.

Pediatric Dosing

Ophthalmic: Safety and efficacy not established; use with extreme caution in pediatric patients.
Topical: Safety and efficacy not established; use sparingly and avoid large surface areas.

Indications

Local anesthesia for minor ocular procedures
Symptomatic relief of pain, itching, and irritation associated with hemorrhoids and minor skin conditions

Mechanism of Action

Acts as an amide-type local anesthetic.
Stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthesia.

Contraindications

Known hypersensitivity to cinchocaine, other amide-type local anesthetics, or any component of the formulation
Application to severely traumatized or infected mucosa and skin
Ophthalmic use in the presence of severe ocular inflammation or infection

Adverse Reactions

Transient stinging, burning, or irritation upon ocular instillation
Allergic contact dermatitis, erythema, and localized edema with topical administration
Systemic toxicity (central nervous system excitation followed by depression, cardiovascular collapse) very rare with standard topical/ophthalmic use

Drug Interactions

Additive local anesthetic effects when used concurrently with other local anesthetics
Increased risk of systemic toxicity when co-administered with potent CYP3A4 inhibitors or other amide anesthetics due to reduced metabolism

Curated Content: Needs Vetting Before Put to Clinical Use