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SENSORY ORGANS › OPHTHALMOLOGICALS › SURGICAL AIDS › Other surgical aids
chymotrypsin
S01KX01
Forms & Strengths
- Ophthalmic solution / powder for reconstitution: 1:5000 units
Adult Dosing
- Zonulolysis: 1-2 mL of 1:5000 solution irrigated into the posterior chamber
- Allow to act for 2 minutes before irrigation with sterile saline
Pediatric Dosing
- Safety and efficacy not established in pediatric populations
- Use restricted to specialized ophthalmic surgical procedures when clinically indicated
Indications
- Enzymatic zonulolysis for intracapsular lens extraction
Mechanism of Action
- Selectively lyses the zonular fibers of the crystalline lens without damaging surrounding ocular structures
- Facilitates removal of the lens during cataract surgery
Contraindications
- Hypersensitivity to chymotrypsin or any component of the formulation
- High risk of vitreous loss (e.g., young patients under 20 years)
- Congenital cataracts
- Active inflammation in the anterior segment
- Wound dehiscence or epithelialization issues
Adverse Reactions
- Transient rise in intraocular pressure
- Striate keratitis (corneal edema)
- Iritis and anterior uveitis
- Delayed wound healing
- Paralysis of accommodation
Drug Interactions
- Inactivated by alcohol, silver nitrate, iodine, and other strong antiseptics
- Local anesthetics containing preservatives (e.g., parabens) may reduce enzymatic activity
Curated Content: Needs Vetting Before Put to Clinical Use