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SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals
ciclosporin
S01XA18
Forms & Strengths
- Ophthalmic emulsion: 0.05%
- Ophthalmic drops/gel: 0.1%
Adult Dosing
- Keratoconjunctivitis sicca: Instill 1 drop into the affected eye(s) twice daily, approximately 12 hours apart.
Pediatric Dosing
- Keratoconjunctivitis sicca (Children >= 16 years): Instill 1 drop into the affected eye(s) twice daily, approximately 12 hours apart.
- Pediatric safety and efficacy in patients < 16 years have not been established.
Indications
- Treatment of chronic dry eye disease (keratoconjunctivitis sicca) associated with ocular inflammation.
Mechanism of Action
- Calcineurin inhibitor acting as an immunomodulatory agent.
- Inhibits calcineurin-dependent pathways, suppressing the release of inflammatory cytokines and reducing T-cell activation in the lacrimal gland and conjunctiva.
Contraindications
- Hypersensitivity to ciclosporin or any excipients in the formulation.
- Active ocular or peri-ocular infections.
Adverse Reactions
- Ocular burning/stinging upon instillation (most common)
- Conjunctival hyperemia
- Blurred vision
- Eye pain, pruritus, or foreign body sensation
- Epiphora
Drug Interactions
- No formal drug interaction studies conducted with topical ophthalmic ciclosporin due to minimal systemic absorption.
- Potential additive effects with concurrent topical ophthalmic NSAIDs or steroids.
Curated Content: Needs Vetting Before Put to Clinical Use