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mercaptamine

S01XA21

Forms & Strengths

Ophthalmic solution 0.1% w/v
Sterile single‑dose ampoules
Preservative‑free formulation

Adult Dosing

Instill 1‑2 drops into the affected eye(s) four times daily
Can be increased to six times daily for severe dry‑eye symptoms
Do not exceed 8 drops per day to avoid ocular surface toxicity

Pediatric Dosing

Instill 1 drop into the affected eye(s) four times daily for children ≥2 years
For infants and toddlers, use 1 drop every 6 hours under ophthalmic supervision
Dose adjustment based on tolerance and severity of ocular irritation

Indications

Dry eye disease (keratoconjunctivitis sicca)
Post‑operative ocular surface inflammation
Mucin deficiency disorders of the corneal epithelium

Mechanism of Action

Thiols reduce disulfide bonds in mucin, enhancing tear film stability
Antioxidant activity scavenges reactive oxygen species on the ocular surface
Promotes epithelial cell migration and wound healing

Contraindications

Known hypersensitivity to mercaptamine or any excipients
Active bacterial, viral or fungal ocular infection
Severe corneal ulceration until infection is controlled

Adverse Reactions

Transient burning or stinging upon instillation
Blurred vision lasting <5 minutes
Conjunctival hyperemia or mild allergic conjunctivitis
Rare corneal epithelial toxicity with excessive dosing

Drug Interactions

Concurrent use with other ophthalmic agents may dilute efficacy; stagger instillation by ≥5 minutes
Avoid simultaneous use with preservative‑containing drops that may increase ocular irritation
Systemic drugs have no significant interaction due to negligible systemic absorption

Curated Content: Needs Vetting Before Put to Clinical Use