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SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals
cenegermin
S01XA24
Forms & Strengths
- Ophthalmic solution 0.002% (20 mcg/mL)
Adult Dosing
- 1 drop in the affected eye(s) 6 times per day at 2-hour intervals for 8 weeks
Pediatric Dosing
- Safety and efficacy in pediatric patients below 2 years of age have not been established
- Use in pediatric patients aged 2 years and older follows the adult dosing regimen (1 drop 6 times daily for 8 weeks)
Indications
- Treatment of neurotrophic keratitis
Mechanism of Action
- Recombinant human nerve growth factor (rhNGF) that binds to TrkA, p75NTR, and sortilin receptors
- Promotes corneal epithelial cell survival, proliferation, and nerve regeneration
Contraindications
- Known hypersensitivity to cenegermin or any of its excipients
Adverse Reactions
- Eye pain
- Corneal deposit
- Foreign body sensation
- Ocular hyperemia
- Inflammation of the eye
- Lacrimation increased
Drug Interactions
- Other topical ophthalmic drugs should be administered at least 15 minutes apart from cenegermin to prevent washing out
- Avoid concurrent use of topical ocular corticosteroids as they may delay corneal healing
Curated Content: Needs Vetting Before Put to Clinical Use