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SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals
riboflavin
S01XA26
Forms & Strengths
- Oral Tablet: 10 mg
- Oral Tablet: 50 mg
- Oral Tablet: 100 mg
- Ophthalmic Solution: 0.1%
Adult Dosing
- Riboflavin deficiency: 5 to 30 mg orally daily in divided doses
- Migraine prophylaxis: 400 mg orally once daily
- Keratoconus (ophthalmic): 0.1% solution with UV-A irradiation (corneal collagen cross-linking)
Pediatric Dosing
- Riboflavin deficiency (neonates): 2 to 4 mg orally daily
- Riboflavin deficiency (children): 3 to 10 mg orally daily in divided doses
- Inborn errors of metabolism: Up to 100 mg orally daily based on specific enzyme defect
Indications
- Treatment and prevention of riboflavin deficiency (ariboflavinosis)
- Prophylaxis of migraine headaches
- Adjunct in corneal collagen cross-linking for keratoconus and corneal ectasia
Mechanism of Action
- Precursor to coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)
- Acts as an electron carrier in biological oxidation-reduction reactions essential for energy metabolism
- Supports cellular growth, respiration, and antibody production
Contraindications
- Hypersensitivity to riboflavin or any component of the formulation
Adverse Reactions
- Bright yellow discoloration of urine (chromaturia), generally harmless
- Polyuria or diarrhea with high-dose oral supplementation
- Transient ocular stinging or irritation with ophthalmic solution
Drug Interactions
- Anticholinergic agents may delay gastrointestinal absorption of riboflavin
- Probenecid decreases the gastrointestinal absorption and renal tubular secretion of riboflavin
- Alcohol decreases dietary absorption of riboflavin
Curated Content: Needs Vetting Before Put to Clinical Use