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SENSORY ORGANS › OTOLOGICALS › ANTIINFECTIVES › Antiinfectives
fosfomycin
S02AA17
Forms & Strengths
- Oral powder for solution: 3 g per packet
Adult Dosing
- Uncomplicated urinary tract infections (acute cystitis): 3 g orally as a single dose
Pediatric Dosing
- Safety and efficacy in pediatric patients under 12 years of age have not been established
Indications
- Treatment of uncomplicated urinary tract infections (acute cystitis) in women caused by susceptible strains of Escherichia coli and Enterococcus faecalis
Mechanism of Action
- Bactericidal broad-spectrum antibiotic that inactivates the cytoplasmic enzyme enolpyruvyl transferase, blocking the first step in bacterial cell wall synthesis
Contraindications
- Known hypersensitivity to fosfomycin or any components of the formulation
Adverse Reactions
- Diarrhea
- Nausea
- Headache
- Vaginitis
- Rhinitis
- Dizziness
Drug Interactions
- Metoclopramide: Concomitant administration lowers gastrointestinal concentrations and serum levels of fosfomycin
- Antacids: May decrease absorption and peak serum concentrations of fosfomycin
Curated Content: Needs Vetting Before Put to Clinical Use