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cefmenoxime

S02AA18

Forms & Strengths

Injectable powder for reconstitution: 1 g, 2 g per vial

Adult Dosing

Severe infections: 1-2 g IV every 6-8 hours
Max daily dose: 12 g IV

Pediatric Dosing

Safety and efficacy not well established in neonates and infants
Severe infections (older children): 50-100 mg/kg/day IV divided every 6-8 hours

Indications

Treatment of susceptible bacterial infections including respiratory tract, urinary tract, intra-abdominal, and skin infections
Septicemia caused by sensitive Gram-positive and Gram-negative organisms

Mechanism of Action

Third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Confers high stability against beta-lactamases produced by many Gram-negative bacteria

Contraindications

Hypersensitivity to cefmenoxime or other cephalosporins
History of immediate hypersensitivity reaction to penicillins

Adverse Reactions

Hypersensitivity reactions including rash, pruritus, and anaphylaxis
Gastrointestinal effects such as diarrhea and nausea
Transient elevation in liver transaminases and BUN
Local reactions at the injection site including phlebitis

Drug Interactions

Aminoglycosides: Potential synergistic nephrotoxicity
Probenecid: Decreases renal tubular secretion of cefmenoxime, increasing plasma concentrations
Alcohol: Disulfiram-like reaction may occur due to the N-methylthiotetrazole side chain

Curated Content: Needs Vetting Before Put to Clinical Use