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prednisolone

S02BA03

Forms & Strengths

Ophthalmic Suspension: 1% (Pred Forte)
Ophthalmic Solution: 0.125%, 1%

Adult Dosing

Ophthalmic: Instill 1 to 2 drops into the conjunctival sac 2 to 4 times daily.
Acute severe inflammation: Up to 1 drop every hour during the day and every 2 hours during the night initially, tapering as inflammation subsides.

Pediatric Dosing

Safety and efficacy in pediatric patients below the age of 2 years have not been established.
Ophthalmic (Children >=2 years): Instill 1 to 2 drops into the conjunctival sac 2 to 4 times daily as directed by physician.

Indications

Treatment of steroid-responsive inflammatory conditions of the palpal and bulbar conjunctiva, cornea, and anterior segment of the globe.

Mechanism of Action

Glucocorticoids inhibit the multiple inflammatory cytokines, reduce edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.

Contraindications

Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
Mycobacterial infection of the eye
Fungal diseases of ocular structures
Hypersensitivity to any component of the formulation

Adverse Reactions

Elevation of intraocular pressure (IOP) with possible development of glaucoma
Posterior subcapsular cataract formation
Delayed wound healing
Secondary ocular infection from pathogens suppressed by steroids
Stinging and burning upon instillation

Drug Interactions

Co-administration with CYP3A4 inhibitors (e.g., ritonavir, cobicistat) may increase systemic exposure and risk of systemic corticosteroid side effects.
Prolonged use with other agents that increase intraocular pressure may result in additive ocular hypertension.

Curated Content: Needs Vetting Before Put to Clinical Use