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SENSORY ORGANS › OTOLOGICALS › OTHER OTOLOGICALS › Analgesics and anesthetics
phenazone
S02DA03
Forms & Strengths
- Otic solution: phenazone 5% with benzocaine 5%
Adult Dosing
- Instill 2 to 4 drops into the external auditory canal 3 times daily or as needed for pain
Pediatric Dosing
- Infants and children: Instill 2 to 4 drops into the external auditory canal 3 times daily or as needed for pain
Indications
- Relief of pain and reduction of inflammation in the acute otitis media (concomitant with systemic antimicrobials)
- Removal of cerumen from the external auditory canal
Mechanism of Action
- Acts as an analgesic and anti-inflammatory agent via inhibition of prostaglandin synthesis in local tissues
- Combined with benzocaine to provide rapid local anesthetic effect on the tympanic membrane and ear canal
Contraindications
- Hypersensitivity to phenazone, pyrazolones, or local anesthetics of the ester type (e.g., benzocaine, procaine)
- Perforated tympanic membrane or known/suspected tympanic membrane rupture
Adverse Reactions
- Local irritation
- Pruritus
- Burning or stinging at application site
- Allergic contact dermatitis
Drug Interactions
- No significant systemic drug interactions expected due to limited absorption from topical otic administration
- Potential additive local hypersensitivity reactions with other topical otic preparations containing related chemical structures
Curated Content: Needs Vetting Before Put to Clinical Use