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neomycin

S03AA01

Forms & Strengths

Ophthalmic solution: 0.35% (neomycin sulfate equivalent to 0.35% neomycin base)
Ophthalmic ointment: 0.35% (neomycin sulfate equivalent to 0.35% neomycin base)
Topical cream/ointment: 0.5% (often combined with other antibiotics like polymyxin B and bacitracin)

Adult Dosing

Ophthalmic infection: Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, or apply a small amount of ointment 3 to 4 times daily depending on severity.
Topical skin infection: Apply a small amount to the affected area 1 to 4 times daily.

Pediatric Dosing

Ophthalmic infection (Pediatric > 2 months): Instill 1 to 2 drops or apply ointment every 3 to 4 hours.
Topical skin infection: Apply a small amount to the affected area 1 to 4 times daily.

Indications

Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused susceptible microorganisms
Prevention of infection in minor cuts, scrapes, and burns on the skin

Mechanism of Action

Binds irreversibly to the 30S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis and causing misreading of genetic code leading to bacterial cell death.

Contraindications

Hypersensitivity to neomycin or any component of the formulation
Fungal or viral infections of the eye or skin
Epithelial herpes simplex keratitis, vaccinia, varicella, and mycobacterial infections of the eye

Adverse Reactions

Local hypersensitivity reactions (contact dermatitis, pruritus, erythema, rash)
Ocular irritation, stinging, burning, or itching upon instillation
Superinfection with non-susceptible organisms or fungi with prolonged use

Drug Interactions

Concurrent use of other ototoxic or nephrotoxic medications (if systemic absorption occurs, though rare with topical/ophthalmic use)
Neuromuscular blocking agents (potential additive neuromuscular blockade)

Curated Content: Needs Vetting Before Put to Clinical Use