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prednisolone

S03BA02

Forms & Strengths

Ophthalmic Suspension: 1% (10 mg/mL)
Ophthalmic Solution: 0.125%

Adult Dosing

Inflammatory conditions: Instill 1 to 2 drops into the conjunctival sac up to 2 to 4 times daily.
Severe inflammation: Instill every hour during the day and every 2 hours during the night initially, tapering as inflammation subsides.

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established.
Use lowest effective dose if prescribed by an ophthalmologist.

Indications

Steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.

Mechanism of Action

Glucocorticoids inhibit the multiple inflammatory cytokines and suppress the immune response.
Decreases vascular permeability, migration of leukocytes, and fibroblast proliferation at the site of inflammation.

Contraindications

Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella.
Mycobacterial infection of the eye.
Fungal diseases of ocular structures.
Hypersensitivity to prednisolone or any component of the formulation.

Adverse Reactions

Elevation of intraocular pressure (IOP) with possible development of glaucoma.
Posterior subcapsular cataract formation.
Delayed wound healing.
Secondary ocular infection (bacterial, fungal, and viral).

Drug Interactions

Concurrent use of topical NSAIDs and topical corticosteroids may delay corneal healing.
Frequent or prolonged use may lead to systemic absorption and interactions typical of systemic corticosteroids.

Curated Content: Needs Vetting Before Put to Clinical Use