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insects

V01AA07

Forms & Strengths

Topical lotion 20% w/w (w/w)
Spray 10% w/w (w/w)
Cream 5% w/w (w/w)
Roll‑on gel 7% w/w (w/w)

Adult Dosing

Apply 1–2 mL per 100 cm² of exposed skin every 8–12 h
Maximum of 4 applications per 24 h
Do not apply to face, mucous membranes, or broken skin

Pediatric Dosing

Children ≥2 years: same amount as adults, but limit to 1 mL per 100 cm²
Children 6 months–2 years: 0.5 mL per 100 cm², max 2 applications/24 h
Contraindicated in infants <6 months

Indications

Prevention of mosquito, tick, and fly bites in outdoor settings
Protection against vector‑borne diseases (e.g., malaria, Lyme disease)
Use for travel to endemic regions

Mechanism of Action

Binds to insect odorant receptors, masking human scent
Inhibits the olfactory pathways that guide insects to host
Provides a non‑lethal repellency lasting 8–12 h at approved concentrations

Contraindications

Known hypersensitivity to picaridin or any formulation excipients
Application to abraded, inflamed, or infected skin
Use on facial mucosa, eyes, or oral cavity

Adverse Reactions

Mild transient skin irritation or erythema
Allergic contact dermatitis (rare)
Pruritus or burning sensation at application site

Drug Interactions

No systemic interactions reported (minimal percutaneous absorption)
Avoid concurrent use with other topical repellents or irritant cosmetics to reduce skin irritation risk
Do not combine with topical anesthetics containing benzocaine without monitoring for additive irritation

Curated Content: Needs Vetting Before Put to Clinical Use