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VARIOUS › DIAGNOSTIC AGENTS › OTHER DIAGNOSTIC AGENTS › Tests for bile duct patency
ceruletide
V04CC04
Forms & Strengths
- Injection: 10 mcg/2 mL ampoules
Adult Dosing
- Pancreatic exocrine function testing: 0.3 mcg/kg subcutaneously or intramuscularly
- Diagnostic visualization of gallbladder/biliary tract: 0.3 mcg/kg
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Diagnostic test for pancreatic exocrine function
- Stimulation of gallbladder contraction for cholecystography
Mechanism of Action
- Synthetic decapeptide analogue of cholecystokinin (CCK)
- Stimulates pancreatic enzyme secretion, gallbladder contraction, and gastric acid secretion
- Increases motility of the small and large intestines
Contraindications
- Known hypersensitivity to ceruletide or caerulein
- Acute pancreatitis
- Biliary tract obstruction
- Pregnancy and lactation
Adverse Reactions
- Abdominal pain and cramping
- Nausea and vomiting
- Flushing and dizziness
- Diarrhea
- Transient changes in blood pressure
Drug Interactions
- Anticholinergic agents may antagonize the gastrointestinal and biliary effects of ceruletide
- Opioid analgesics may blunt the biliary and pancreatic response
Curated Content: Needs Vetting Before Put to Clinical Use