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VARIOUS › DIAGNOSTIC AGENTS › OTHER DIAGNOSTIC AGENTS › Tests for pituitary function
corticorelin
V04CD04
Forms & Strengths
- Injectable powder for reconstitution: 100 mcg per vial
Adult Dosing
- Diagnostic test for Cushing's syndrome: 1 mcg/kg administered intravenously as a single bolus injection
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Differential diagnosis of Cushing's syndrome (pituitary ACTH-dependent Cushing's disease vs. ectopic ACTH syndrome or adrenal tumors)
Mechanism of Action
- Synthetic human corticotropin-releasing hormone (CRH) that binds to specific pituitary membrane receptors, stimulating the synthesis and secretion of adrenocorticotropic hormone (ACTH)
Contraindications
- Hypersensitivity to human corticorelin or any component of the formulation
- Pregnancy
Adverse Reactions
- Facial flushing
- Dyspnea
- Metallic taste
- Lightheadedness
- Nausea
- Transient tachycardia
- Hypotension
Drug Interactions
- Glucocorticoids may blunt the ACTH response and should be withheld prior to testing
- Cyproheptadine may inhibit the ACTH response to corticorelin
- Opiates and other central nervous system active drugs may interfere with hypothalamic-pituitary-adrenal axis testing
Curated Content: Needs Vetting Before Put to Clinical Use