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indocyanine green

V04CX01

Forms & Strengths

Powder for reconstitution: 25 mg vial
Powder for reconstitution: 50 mg vial

Adult Dosing

Cardiac output: 5 mg to 10 mg per injection as a sterile aqueous solution
Hepatic function: 0.5 mg/kg body weight intravenously
Ophthalmic angiography: 40 mg in 2 mL sterile water for injection

Pediatric Dosing

Cardiac output: 0.25 mg to 0.5 mg per injection (safety and efficacy not fully established)
Angiography: Dose adjusted based on body weight and clinical judgment

Indications

Determination of cardiac output and stroke volume
Hepatic function and blood flow evaluation
Fluorescence angiography of the choroidal and retinal vasculature

Mechanism of Action

Binds strongly to plasma proteins upon intravenous administration, remaining almost exclusively in the intravascular space
Absorbs and emits light in the near-infrared spectrum (peak absorption ~805 nm)
Cleared rapidly and almost exclusively by the liver into the bile without significant extrahepatic metabolism

Contraindications

Hypersensitivity to indocyanine green
Iodide allergy (contains sodium iodide)

Adverse Reactions

Anaphylactic or urticarial reactions
Nausea and vomiting
Flushing and sweating
Hypotension or tachycardia

Drug Interactions

Anticoagulants may alter hepatic blood flow measurements
Bisulfites (sodium bisulfite injection) can reduce absorption peak of indocyanine green
Narcotics and barbiturates may alter cardiac output measurements

Curated Content: Needs Vetting Before Put to Clinical Use