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pafolacianine

V04CX10

Forms & Strengths

Intravenous solution: 0.32 mg/mL in a single-dose vial

Adult Dosing

0.025 mg/kg intravenously administered 1 hour prior to surgery (range: 1 to 2.4 hours before start of fluorescence imaging)

Pediatric Dosing

Safety and effectiveness in pediatric patients have not been established

Indications

As an adjunct for intraoperative identification of ovarian cancer lesions in patients with known or suspected ovarian cancer

Mechanism of Action

Optical imaging agent that binds to folate receptors (FR-alpha) expressed on ovarian cancer cells, which are then visualized under near-infrared fluorescence imaging during surgery

Contraindications

Known hypersensitivity to pafolacianine or its components
Pregnancy

Adverse Reactions

Infusion-related reactions
Nausea
Vomiting
Abdominal pain
Flushing
Dyspnea
Chest discomfort
Rash
Pruritus

Drug Interactions

Folate supplementation (e.g., folic acid) may competitively bind to folate receptors and reduce the efficacy of pafolacianine; avoid folate-containing supplements 48 hours prior to administration

Curated Content: Needs Vetting Before Put to Clinical Use