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metrizoic acid

V08AA02

Forms & Strengths

Injectable solution (as sodium and/or meglumine salts), various concentrations (e.g., 60%, 75%)

Adult Dosing

Varies by diagnostic procedure (e.g., excretion urography, angiocardiography, cerebral angiography)
Dose range: 10 mL to 60 mL per administration, depending on the specific radiological indication and technique used

Pediatric Dosing

Safety and efficacy in pediatric patients are not fully established; use lowest effective dose if deemed necessary by specialist
Dosing must be individualized based on age, body weight, and clinical condition

Indications

Diagnostic radiocontrast agent for excretory urography
Angiocardiography
Peripheral and cerebral arteriography
Venography

Mechanism of Action

Contains organically bound iodine that absorbs X-rays, thereby enhancing visualization of blood vessels, urinary tract, and other internal structures during radiographic imaging

Contraindications

Known hypersensitivity to metrizoic acid or other iodinated contrast media
Manifest hyperthyroidism
Severe dehydration

Adverse Reactions

Mild to moderate anaphylactoid reactions (urticaria, nausea, vomiting, flushing)
Injection site reactions (pain, warmth)
Rare severe adverse events: severe anaphylaxis, bronchospasm, hypotension, renal impairment, cardiac arrhythmias

Drug Interactions

Interferes with thyroid uptake of radioactive iodine
Increased risk of renal toxicity when administered concurrently with nephrotoxic drugs (e.g., aminoglycosides, NSAIDs)
Biguanides (metformin) may accumulate and induce lactic acidosis if acute renal impairment occurs post-contrast administration

Curated Content: Needs Vetting Before Put to Clinical Use