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iocarmic acid

V08AA08

Forms & Strengths

Injectable solution 50% to 70% iodine concentration

Adult Dosing

Dose varies widely by diagnostic procedure (arthrography, hysterosalpingography, cisternography)
Typically 1 mL to 20 mL depending on anatomical site and imaging modality

Pediatric Dosing

Safety and efficacy in pediatric patients not thoroughly established
Use restricted to specialized diagnostic procedures under expert supervision with reduced weight-based dosing

Indications

Radiopaque contrast medium for diagnostic radiography
Used in arthrography, hysterosalpingography, and specialized neuroradiological procedures

Mechanism of Action

Contains organically bound iodine which absorbs X-rays, thereby enhancing radiographic visualization of internal anatomical structures

Contraindications

Known hypersensitivity to iocarmic acid or other iodinated contrast agents
Manifest hyperthyroidism
Severe systemic infections or acute inflammation in areas of direct injection

Adverse Reactions

Injection site pain and localized inflammation
Mild hypersensitivity reactions including urticaria, pruritus, and flushing
Rare severe anaphylactoid reactions, bronchospasm, and hypotension
Chemical synovitis when used inappropriately in arthrography

Drug Interactions

Beta-blockers may exacerbate severe hypersensitivity reactions and blunt response to epinephrine
Interferes with thyroid function tests utilizing radioactive iodine uptake for several weeks post-administration
Metformin should be temporarily discontinued in patients with renal impairment receiving intravascular iodinated contrast

Curated Content: Needs Vetting Before Put to Clinical Use