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VARIOUS › CONTRAST MEDIA › X-RAY CONTRAST MEDIA, IODINATED › Watersoluble, nephrotropic, high osmolar X-ray contrast media
diodone
V08AA10
Forms & Strengths
- Intravenous solution 35% w/v
- Intravenous solution 50% w/v
- Radiopaque contrast medium
Adult Dosing
- Excretory urography: 20 mL of 35% or 50% solution administered intravenously
- Angiography: 10 mL to 20 mL depending on the vessel targeted
Pediatric Dosing
- Safety and efficacy not well established; use is discouraged unless clinically necessary
- Dose adjusted downward based on body weight and clinical indication per institutional radiologic protocol
Indications
- Excretory urography (intravenous pyelography)
- Peripheral angiography
- Visualization of the urinary tract and vascular system
Mechanism of Action
- Contains iodine molecules that absorb X-rays significantly more than surrounding soft tissues
- Provides radiopacity to blood vessels and the urinary tract during excretory procedures
Contraindications
- Known hypersensitivity to iodinated contrast media
- Severe renal impairment
- Decompensated heart failure
- Active severe thyrotoxicosis
Adverse Reactions
- Anaphylactoid reactions including urticaria, bronchospasm, and hypotension
- Nausea and vomiting
- Transient flushing and warmth
- Nephrotoxicity in vulnerable patients
- Pain and extravasation at the injection site
Drug Interactions
- Metformin (increased risk of lactic acidosis upon contrast-induced renal dysfunction)
- Nephrotoxic drugs such as aminoglycosides and NSAIDs (increased risk of acute kidney injury)
- Beta-blockers (may worsen severe hypersensitivity or anaphylactoid reactions and reduce responsiveness to epinephrine)
Curated Content: Needs Vetting Before Put to Clinical Use