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ioversol

V08AB07

Forms & Strengths

Injection: 51% (242 mg iodine/mL)
Injection: 68% (320 mg iodine/mL)
Injection: 74% (350 mg iodine/mL)

Adult Dosing

Intravenous urography: 50 to 100 mL of 68% or 74% solution
Computed tomography (CT) head/body: 50 to 200 mL depending on concentration and scan type
Intravascular angiography: Individualized based on vessel size and procedure (typically 5 to 100 mL)

Pediatric Dosing

Intravenous urography: 1 to 2 mL/kg of 68% solution (max 3 mL/kg)
CT imaging: 1 to 2 mL/kg of 51% or 68% solution

Indications

Diagnostic contrast agent for intravascular angiography
Contrast-enhanced computed tomography (CT) head and body imaging
Excretory urography

Mechanism of Action

Low-osmolar, non-ionic, water-soluble iodinated radiographic contrast agent
Tri-iodinated benzene ring structure minimizes systemic toxicity and osmolality compared to ionic agents
Absorbs X-radiation, providing high-contrast visualization of blood vessels and anatomical structures during imaging

Contraindications

Known hypersensitivity to ioversol or other iodinated contrast media
Manifest thyrotoxicosis

Adverse Reactions

Transient heat sensation, pain, or flushing at injection site
Nausea, vomiting, and headache
Hypersensitivity reactions ranging from mild urticaria to severe anaphylaxis
Contrast-induced nephropathy (particularly in patients with preexisting renal impairment)
Extravasation leading to local tissue irritation and swelling

Drug Interactions

Metformin: Risk of lactic acidosis due to acute contrast-induced renal dysfunction; withhold metformin at time of or prior to procedure
Nephrotoxic drugs (e.g., aminoglycosides, NSAIDs): Increased risk of renal impairment
Beta-blockers: May exacerbate severe hypersensitivity/anaphylactoid reactions and reduce responsiveness to epinephrine rescue

Curated Content: Needs Vetting Before Put to Clinical Use