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VARIOUS › CONTRAST MEDIA › X-RAY CONTRAST MEDIA, IODINATED › Watersoluble, nephrotropic, low osmolar X-ray contrast media
iomeprol
V08AB10
Forms & Strengths
- Injectable solution 140 mg iodine/mL
- Injectable solution 200 mg iodine/mL
- Injectable solution 250 mg iodine/mL
- Injectable solution 300 mg iodine/mL
- Injectable solution 350 mg iodine/mL
- Injectable solution 400 mg iodine/mL
Adult Dosing
- Intravenous urography: 50-100 mL of 300-350 mg iodine/mL
- Computed tomography (CT) enhancement: 50-150 mL of 250-350 mg iodine/mL
- Digital subtraction angiography (DSA): 20-60 mL per injection of 300-350 mg iodine/mL
- Arteriography and venography: Dosing varies widely by anatomical site and procedure, typically 10-100 mL
Pediatric Dosing
- Computed tomography (CT): 1-2 mL/kg of body weight of 240-300 mg iodine/mL
- Intravenous urography: 1-2 mL/kg of body weight of 300 mg iodine/mL
- Dosing must be minimized to the lowest effective concentration and volume in neonates and infants
Indications
- X-ray contrast medium for diagnostic procedures
- Intravenous excretory urography
- Computed tomography (CT) imaging of the brain and body
- Angiography including cerebral, coronary, peripheral arteriography, and venography
Mechanism of Action
- Non-ionic, monomeric water-soluble iodinated X-ray contrast agent
- Triiodinated benzene ring structure provides high radiopacity due to high atomic number of iodine
- Absorbs X-radiation, enhancing visualization of blood vessels, organs, and anatomical structures during radiographic imaging
- Low osmolality relative to ionic contrast agents reduces patient discomfort and hemodynamic side effects
Contraindications
- Known hypersensitivity to iomeprol or any component of the formulation
- Manifest thyrotoxicosis
- Hysterosalpingography during pregnancy or acute pelvic inflammatory disease (if applicable formulation)
Adverse Reactions
- Mild warmth, flushing, or metallic taste immediately post-injection
- Nausea and vomiting
- Transient headache or dizziness
- Hypersensitivity reactions ranging from mild urticaria to severe anaphylaxis
- Contrast-induced nephropathy, particularly in patients with pre-existing renal impairment
Drug Interactions
- Interleukins: Increased risk of delayed hypersensitivity reactions (fever, rash, arthralgia, flu-like symptoms)
- Metformin: Risk of lactic acidosis in patients with acute renal failure or severe chronic kidney disease; discontinue metformin at time of or prior to procedure
- Nephrotoxic drugs (e.g., aminoglycosides, NSAIDs): Increased risk of renal impairment when administered with iodinated contrast agents
- Beta-blockers: May reduce the efficacy of treatment for acute hypersensitivity reactions and increase risk of bronchospasm
Curated Content: Needs Vetting Before Put to Clinical Use