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VARIOUS › CONTRAST MEDIA › X-RAY CONTRAST MEDIA, IODINATED › Watersoluble, nephrotropic, low osmolar X-ray contrast media
iobitridol
V08AB11
Forms & Strengths
- Injectable solution 250 mg iodine/mL
- Injectable solution 300 mg iodine/mL
- Injectable solution 350 mg iodine/mL
Adult Dosing
- X-ray contrast imaging: Dose varies widely based on examination type, technique, and vascular/cavity site.
- Intravenous urography: 50 to 100 mL of 300 or 350 mg I/mL.
- Computed tomography (CT): 50 to 150 mL depending on target organ and protocol.
- Arteriography and angiography: Individualized volume per injection based on anatomical site.
Pediatric Dosing
- Safety and efficacy in pediatric patients are not fully established; use lowest effective dose if administered.
- Angiography/Urography in children: Dosing scaled strictly by body weight (typically 1 to 2 mL/kg of appropriate iodine concentration).
Indications
- Diagnostic contrast agent for X-ray imaging
- Intravenous urography
- Computed tomography (CT) enhancement of the brain and body
- Angiography and arteriography
- Venography and hysterosalpingography
Mechanism of Action
- Tri-iodinated, non-ionic, water-soluble radiographic contrast medium.
- Absorbs X-radiation due to the high atomic number of iodine atoms.
- Temporarily increases radiopacity of blood vessels, tissues, and body cavities to enhance visualization on diagnostic imaging.
Contraindications
- Known hypersensitivity to iobitridol or other iodinated contrast media
- Manifest hyperthyroidism
- Hysterosalpingography during acute pelvic inflammatory disease or pregnancy
Adverse Reactions
- Mild transient warmth, flushing, metallic taste, or nausea during injection
- Hypersensitivity reactions ranging from mild urticaria to severe anaphylaxis
- Contrast-induced nephropathy (particularly in patients with preexisting renal impairment)
- Extravasation leading to local tissue irritation, swelling, or necrosis
Drug Interactions
- Concomitant nephrotoxic medications (e.g., NSAIDs, aminoglycosides) increase risk of renal impairment.
- Interferes with thyroid uptake of radioiodine for up to several weeks post-administration.
- Biguanides (metformin) may accumulate if acute renal failure occurs, increasing risk of lactic acidosis; discontinue metformin prior to or at time of procedure.
Curated Content: Needs Vetting Before Put to Clinical Use