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VARIOUS › CONTRAST MEDIA › X-RAY CONTRAST MEDIA, IODINATED › Watersoluble, hepatotropic X-ray contrast media
iotroxic acid
V08AC02
Forms & Strengths
- Intravenous solution 50% to 75% w/v bound iodine
Adult Dosing
- Intravenous cholangiography: 30 to 50 mL of solution administered slowly over 1 to 2 minutes
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Diagnostic visualization of the biliary tract via intravenous cholangiography
Mechanism of Action
- Triiodinated benzoic acid derivative that absorbs X-rays, providing contrast enhancement of the biliary tree following selective hepatocyte uptake and biliary excretion
Contraindications
- Known hypersensitivity to iotroxic acid or other iodinated contrast media
- Severe manifest hyperthyroidism
- Severe renal or hepatic impairment
- Decompensated cardiac insufficiency
Adverse Reactions
- Nausea and vomiting
- Flush and sensation of heat
- Transient pain at injection site
- Hypersensitivity reactions ranging from mild urticaria to severe anaphylactoid shock
- Transient alterations in renal or hepatic laboratory parameters
Drug Interactions
- Interferes with thyroid function tests (radioactive iodine uptake) for several weeks
- Increased risk of lactic acidosis in patients taking metformin with acute renal impairment
- Potential nephrotoxicity when co-administered with other nephrotoxic drugs
Curated Content: Needs Vetting Before Put to Clinical Use