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sodium iopodate

V08AC08

Forms & Strengths

Iodinated, water‑soluble contrast solution for intravenous injection
300 mg I/mL (iodine) in 250 mL ampoule
Available as single‑dose vials

Adult Dosing

CT angiography: 1.5–2.0 mL/kg body weight, max 200 mL
Urography: 0.5–1.0 mL/kg, max 150 mL
Inject at 2–3 mL/s using power injector
Flush with 30–50 mL saline after administration

Pediatric Dosing

Children < 12 yr: 0.3–0.5 mL/kg, max 100 mL
Infants < 1 yr: 0.2–0.3 mL/kg, max 50 mL
Inject rate 1–2 mL/s; adjust for cardiac output

Indications

Contrast‑enhanced CT of head, chest, abdomen, pelvis
Digital subtraction angiography
Intravenous urography
Perfusion studies and vascular mapping

Mechanism of Action

Iodine atoms provide high atomic number, absorb X‑rays
Transiently increases vascular attenuation, enhancing image contrast

Contraindications

Known hypersensitivity to iodine‑based contrast
Uncontrolled hyperthyroidism or thyroid storm
Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
Pregnancy unless essential
Breastfeeding (consider interruption)

Adverse Reactions

Mild: warmth, flushing, metallic taste, nausea, vomiting
Moderate: urticaria, bronchospasm, hypotension
Severe: anaphylactoid reaction, laryngeal edema, cardiac arrest
Contrast‑induced nephropathy (rise in serum creatinine)
Thyroid dysfunction: hyper‑ or hypothyroidism

Drug Interactions

Beta‑blockers may mask tachycardia during anaphylaxis
Metformin: hold before and 48 h after contrast to avoid lactic acidosis
ACE inhibitors, ARBs, NSAIDs, diuretics increase nephrotoxicity risk
Iodinated drugs (e.g., amiodarone) potentiate thyroid effects
Radiopharmaceuticals: timing adjustments may be required

Curated Content: Needs Vetting Before Put to Clinical Use