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calcium iopodate

V08AC10

Forms & Strengths

Calcium iopodate 60% solution (300 mg I/mL) for IV/IA injection
Calcium iopodate 60% oral suspension for GI studies

Adult Dosing

IV/IA: 100‑150 mL (30‑45 g I) for angiography; titrate to opacify vessels
CT: 1‑2 mL/kg (max 150 mL) IV bolus, followed by saline flush
Oral GI study: 30‑50 mL diluted with water, sip slowly

Pediatric Dosing

IV/IA: 0.5‑1 mL/kg (max 100 mL) for angiography; adjust for cardiac output
CT: 1‑2 mL/kg IV, not exceeding adult max
Oral: 0.5‑1 mL/kg diluted, max 30 mL

Indications

Contrast‑enhanced radiography (urography, arthrography)
Angiography of cerebral, coronary, peripheral vessels
CT angiography and body imaging
Oral contrast for upper GI series and barium‑substituted studies

Mechanism of Action

Water‑soluble, non‑ionic iodinated contrast; iodine atoms absorb X‑rays, increasing radiodensity of blood/tissues
Provides high‑contrast opacification without chemical binding

Contraindications

Known severe hypersensitivity to iodinated contrast
Uncontrolled hyperthyroidism or thyroid storm
Severe renal impairment (eGFR <30 mL/min/1.73 m²)
Acute pulmonary edema or severe heart failure

Adverse Reactions

Warmth or flushing sensation
Metallic taste, nausea, vomiting
Urticaria, maculopapular rash, pruritus
Hypotension or hypertension spikes
Contrast‑induced nephropathy (rise in serum creatinine)
Thyroid dysfunction (hyper‑ or hypothyroidism)
Rare anaphylactoid reactions, bronchospasm

Drug Interactions

Nephrotoxic agents (aminoglycosides, NSAIDs, IV contrast) ↑ risk of CIN
Metformin: hold 48 h after contrast in renal impairment to avoid lactic acidosis
Iodine‑containing drugs (amiodarone, thyroid hormone) may alter thyroid labs
Diuretics and ACE inhibitors increase CIN risk
Beta‑blockers may blunt tachycardia response to contrast

Curated Content: Needs Vetting Before Put to Clinical Use