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technetium (99mTc) lidofenin

V09DA03

Forms & Strengths

Kit for the preparation of technetium Tc 99m lidofenin injection (lyophilized powder)
Radiopharmaceutical diagnostic agent requiring reconstitution with sodium pertechnetate Tc 99m

Adult Dosing

Intravenous injection of 37 to 185 MBq (1 to 5 mCi) of technetium Tc 99m lidofenin
Administered as a single diagnostic dose prior to hepatobiliary scintigraphy imaging

Pediatric Dosing

0.05 to 0.1 mL/kg of reconstituted solution administered intravenously
Minimum recommended dose is 0.5 mCi (18.5 MBq) to ensure adequate visualization
Safety and efficacy in neonates and infants under strict clinical evaluation

Indications

Hepatobiliary imaging for differential diagnosis of acute cholecystitis
Evaluation of biliary tract patency, bile leaks, and congenital biliary abnormalities such as biliary atresia

Mechanism of Action

Lidofenin is selectively taken up by hepatocytes via active transport mechanisms in the liver
Rapidly excreted into the bile, outlining the biliary tree, gallbladder, and small intestine
Radiolabeled with technetium-99m to allow gamma camera scintigraphy visualization of hepatobiliary function

Contraindications

Known hypersensitivity to lidofenin or other iminodiacetic acid (IDA) derivatives
Pregnancy and lactation unless diagnostic benefits clearly outweigh potential radiation risks

Adverse Reactions

Rare hypersensitivity reactions including rash, urticaria, and pruritus
Transient nausea, dizziness, or flushing during intravenous administration

Drug Interactions

Opioid analgesics may cause spasm of the sphincter of Oddi, altering hepatobiliary transit times and mimicking biliary obstruction
Recent meals or total parenteral nutrition stimulate gallbladder contraction or keep it contracted, interfering with optimal diagnostic visualization

Curated Content: Needs Vetting Before Put to Clinical Use