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technetium (99mTc) macrosalb

V09EB01

Forms & Strengths

Kit for the preparation of technetium Tc 99m macrosalb injection: lyophilized powder in multiple-dose vials

Adult Dosing

Lung scintigraphy: 37 to 148 MBq (1 to 4 mCi) administered intravenously
Dose determined by number of particles (typically 200,000 to 700,000) to avoid excessive occlusion of pulmonary capillaries

Pediatric Dosing

Lung scintigraphy: 0.5 to 1.5 MBq/kg body weight administered intravenously
Minimum recommended dose: 7.4 MBq (0.2 mCi)
Particle number reduced proportionally based on age and body surface area

Indications

Lung scintigraphy for the assessment of pulmonary perfusion
Evaluation of suspected pulmonary embolism
Right-to-left shunt detection (with brain or whole-body imaging)

Mechanism of Action

Technetium Tc 99m macroaggregated albumin (MAA) particles are trapped temporarily in the pulmonary capillary bed via microembolization
Distribution of trapped radioactive particles is proportional to regional pulmonary blood flow

Contraindications

Known hypersensitivity to human serum albumin or technetium Tc 99m preparations
Severe pulmonary hypertension (relative contraindication due to risk of complete capillary bed blockage)
Right-to-left cardiac shunts require significant dose reduction to prevent cerebral or systemic microembolization

Adverse Reactions

Hypersensitivity and anaphylactic reactions (rare)
Fever, chills, nausea, and flushing (very rare)
Transient dyspnea or chest discomfort in patients with severe pulmonary hypertension

Drug Interactions

Substances that alter regional pulmonary blood flow can affect scan interpretation
Previous administration of other particulate radiopharmaceuticals may interfere with particle number calculations

Curated Content: Needs Vetting Before Put to Clinical Use