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technetium (99mTc) microspheres

V09EB02

Forms & Strengths

Kit for the preparation of technetium Tc 99m labeled human albumin microspheres for injection
Vials containing human albumin microspheres with stannous chloride as a reducing agent

Adult Dosing

Lung scintigraphy: 37 to 185 MBq (1 to 5 mCi) administered intravenously
Dose adjusted based on clinical evaluation and nuclear medicine imaging guidelines

Pediatric Dosing

Lung scintigraphy: 0.5 to 1.5 MBq/kg body weight administered intravenously
Minimum recommended dose: 18.5 MBq (0.5 mCi) adjusted for pediatric body surface area

Indications

Lung perfusion scintigraphy for the assessment of pulmonary capillary perfusion
Evaluation of suspected pulmonary embolism

Mechanism of Action

Microspheres (diameter 10 to 100 micrometers) are injected intravenously and become temporarily trapped in the precapillary arterioles and capillaries of the lungs
Distribution of trapped microspheres is directly proportional to regional pulmonary blood flow

Contraindications

Severe pulmonary hypertension
Right-to-left cardiac shunts due to the risk of systemic arterial embolization
Known hypersensitivity to human serum albumin or any component of the preparation

Adverse Reactions

Hypersensitivity and anaphylactic reactions (rare)
Fever, chills, nausea, and flushing
Transient dyspnea or chest discomfort in patients with severe pulmonary hypertension

Drug Interactions

Drugs that alter pulmonary blood flow or vascular tone may affect the regional distribution of the microspheres
No significant pharmacological drug-drug interactions known due to the microgram quantities of active ingredients

Curated Content: Needs Vetting Before Put to Clinical Use