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technetium (99mTc) human albumin

V09GA04

Forms & Strengths

Kit for the preparation of technetium Tc 99m human serum albumin injection
Lyophilized powder in multidose vials for radiolabeling with sodium pertechnetate Tc 99m

Adult Dosing

Blood pool imaging and cardiovascular scanning: 185 to 370 MBq (5 to 10 mCi) IV
Placental localization: 37 to 111 MBq (1 to 3 mCi) IV
Lung scintigraphy / protein-losing enteropathy: 37 to 185 MBq (1 to 5 mCi) IV

Pediatric Dosing

Cardiovascular imaging: 1.5 to 3.7 MBq/kg (0.04 to 0.10 mCi/kg) IV
Minimum recommended dose: 18.5 MBq (0.5 mCi)
Adjusted downward based on body weight according to pediatric dosing charts

Indications

Measurement of cardiac output and blood pool imaging
Placental localization in suspected placenta previa
Delineation of heart chambers and great vessels
Detection of protein-losing enteropathy

Mechanism of Action

Human serum albumin is radiolabeled with metastable technetium-99m
Temporarily remains within the intravascular blood pool following intravenous injection
Allows gamma camera scintigraphy to visualize cardiac chambers, vascular structures, and regional blood volume

Contraindications

Known hypersensitivity to human serum albumin or any component of the radiopharmaceutical preparation
Pregnancy, unless the clinical benefit clearly outweighs the potential risk of radiation to the fetus

Adverse Reactions

Hypersensitivity and anaphylactic reactions (urticaria, chills, nausea, hypotension)
Injection site reactions
Fever and flushing

Drug Interactions

Any agent that alters cardiovascular dynamics or blood volume may affect cardiac pool imaging results
No specific pharmacodynamic drug-drug interactions known due to tracer quantities administered

Curated Content: Needs Vetting Before Put to Clinical Use