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iodine (125I) human albumin

V09GB02

Forms & Strengths

Diagnostic solution for intravenous injection
Radioactivity concentration varies by manufacturer/calibration date, typically approx 3.7 MBg/mL (0.1 mCi/mL)

Adult Dosing

Blood volume determination: 37 to 185 kBq (1 to 5 microcuries) IV once
Cardiac output and cardiac output studies: 185 to 370 kBq (5 to 10 microcuries) IV once

Pediatric Dosing

Safety and efficacy not well established in pediatric patients; use only when clinically justified with appropriately reduced weight- or surface area-based doses

Indications

Determination of total blood volume and plasma volume
Cardiac output measurement
Protein turnover studies and localization of cerebral tumors (historical/specialized)

Mechanism of Action

Human serum albumin radiolabeled with iodine-125 acts as a vascular tracer
Remains intravascularly for a sufficient period to allow mixing and measurement of blood and plasma volume before gradual extravasation and metabolic degradation

Contraindications

Known hypersensitivity to human serum albumin or iodine-125
Pregnancy and lactation (unless diagnostic benefit outweighs high potential risk of fetal radiation)

Adverse Reactions

Hypersensitivity reactions including anaphylaxis, urticaria, chills, and fever
Vasomotor reactions and flushing
Injection site reactions

Drug Interactions

Other blood volume expanders or plasma substitutes can alter baseline distribution volume and invalidate measurement accuracy
Radiopaque contrast media and concurrent radioactive diagnostic agents can interfere with counting equipment and baseline radioactivity measurements

Curated Content: Needs Vetting Before Put to Clinical Use