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VARIOUS › DIAGNOSTIC RADIOPHARMACEUTICALS › TUMOUR DETECTION › Technetium (99mTc) compounds
technetium (99mTc) trofolastat chloride
V09IA10
Forms & Strengths
- Kit for the preparation of technetium Tc 99m trofolastat injection
Adult Dosing
- 370 to 740 MBq (10 to 20 mCi) administered as a single intravenous injection
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Radiopharmaceutical diagnostic imaging for prostate-specific membrane antigen (PSMA) positive lesions in prostate cancer
Mechanism of Action
- Binds to prostate-specific membrane antigen (PSMA), allowing visualization of PSMA-expressing tissues via single-photon emission computed tomography (SPECT)
Contraindications
- Hypersensitivity to the active substance or any excipients
Adverse Reactions
- Nausea
- Fatigue
- Injection site reactions
- Dysgeusia
- Dizziness
Drug Interactions
- Androgen deprivation therapy (ADT) and other PSMA-targeting agents may influence the uptake of technetium Tc 99m trofolastat
Curated Content: Needs Vetting Before Put to Clinical Use